CATH Classification

Domain Context

CATH Clusters

Superfamily NAD(P)-binding Rossmann-like Domain
Functional Family 3-oxoacyl-[acyl-carrier-protein] reductase FabG1

Enzyme Information

1.1.1.100
3-oxoacyl-[acyl-carrier-protein] reductase.
based on mapping to UniProt P9WGT3
(3R)-3-hydroxyacyl-[acyl-carrier-protein] + NADP(+) = 3-oxoacyl-[acyl- carrier-protein] + NADPH.
-!- Exhibits a marked preference for [acyl-carrier-protein] derivatives over CoA derivatives as substrates.

UniProtKB Entries (1)

P9WGT3
FABG_MYCTU
Mycobacterium tuberculosis H37Rv
3-oxoacyl-[acyl-carrier-protein] reductase FabG1

PDB Structure

PDB 1UZM
External Links
Method X-RAY DIFFRACTION
Organism
Primary Citation
Crystal Structure of Maba from Mycobacterium Tuberculosis, a Reductase Involved in Long-Chain Fatty Acid Biosynthesis.
Cohen-Gonsaud, M., Ducasse, S., Hoh, F., Zerbib, D., Labesse, G., Quemard, A.
J.Mol.Biol.