CATH Classification
Level | CATH Code | Description |
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3 | Alpha Beta |
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3.30 | 2-Layer Sandwich |
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3.30.387 | Viral Envelope Glycoprotein; domain 3 |
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3.30.387.10 | Viral Envelope Glycoprotein, domain 3 |
Domain Context
CATH Clusters
Superfamily | Viral Envelope Glycoprotein, domain 3 |
Functional Family | Envelope glycoprotein |
Enzyme Information
2.1.1.56 |
mRNA (guanine-N(7)-)-methyltransferase.
based on mapping to UniProt P27915
S-adenosyl-L-methionine + G(5')pppR-RNA = S-adenosyl-L-homocysteine + m(7)G(5')pppR-RNA.
-!- Adds an N(7)-methylguanine cap to mRNA. -!- The nucleoside next to the terminal guanosine may be either guanosine or adenosine.
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2.1.1.57 |
Methyltransferase cap1.
based on mapping to UniProt P27915
S-adenosyl-L-methionine + a 5'-(N(7)-methyl 5'-triphosphoguanosine)- (purine-ribonucleotide)-[mRNA] = S-adenosyl-L-homocysteine + a 5'-(N(7)- methyl 5'-triphosphoguanosine)-(2'-O-methyl-purine-ribonucleotide)- [mRNA].
-!- This enzyme catalyzes the methylation of the ribose on the first transcribed nucleotide of mRNA or snRNA molecules, which may be either guanosine or adenosine. -!- This methylation event is known as cap1, and occurs in all mRNAs and snRNAs of higher eukaryotes, including insects, vertebrates and their viruses. -!- The human enzyme can also methylate mRNA molecules that lack methylation on the capping 5'-triphosphoguanosine. -!- Formerly EC 2.1.1.58.
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3.6.4.13 |
RNA helicase.
based on mapping to UniProt P27915
ATP + H(2)O = ADP + phosphate.
-!- RNA helicases utilize the energy from ATP hydrolysis to unwind RNA. -!- Some of them unwind RNA with a 3' to 5' polarity, other show 5' to 3' polarity. -!- Some helicases unwind DNA as well as RNA. -!- May be identical with EC 3.6.4.12 (DNA helicase).
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3.4.21.91 |
Flavivirin.
based on mapping to UniProt P27915
Selective hydrolysis of -Xaa-Xaa-|-Yaa- bonds in which each of the Xaa can be either Arg or Lys and Yaa can be either Ser or Ala.
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3.6.1.15 |
Nucleoside-triphosphate phosphatase.
based on mapping to UniProt P27915
NTP + H(2)O = NDP + phosphate.
-!- The enzyme is found in eukaryotes and thermophilic bacteria, but appears to be absent from mesophilic bacteria. -!- Also hydrolyzes nucleoside diphosphates, thiamine diphosphate and FAD. -!- The enzyme from the plant Pisum sativum (garden pea) is regulated by calmodulin.
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2.7.7.48 |
RNA-directed RNA polymerase.
based on mapping to UniProt P27915
Nucleoside triphosphate + RNA(n) = diphosphate + RNA(n+1).
-!- Catalyzes RNA-template-directed extension of the 3'-end of an RNA strand by one nucleotide at a time. -!- Can initiate a chain de novo. -!- See also EC 2.7.7.6.
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UniProtKB Entries (1)
P27915 |
POLG_DEN3P
Dengue virus 3 Philippines/H87/1956
Genome polyprotein
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PDB Structure
PDB | 1UZG |
External Links | |
Method | X-RAY DIFFRACTION |
Organism | |
Primary Citation |
Variable Surface Epitopes in the Crystal Structure of Dengue Virus Type 3 Envelope Glycoprotein
J.Virol.
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