CATH Classification

Domain Context

CATH Clusters

Superfamily 3.40.50.970
Functional Family Acetolactate synthase

Enzyme Information

2.5.1.66
N(2)-(2-carboxyethyl)arginine synthase.
based on mapping to UniProt Q9LCV9
D-glyceraldehyde 3-phosphate + L-arginine = N(2)-(2-carboxyethyl)-L- arginine + phosphate.
-!- Requires thiamine diphosphate and catalyzes the first step in the clavulanic-acid biosynthesis pathway. -!- The 2-hydroxy-3-oxo group transferred from glyceraldehyde 3-phosphate is isomerized during transfer to form the 2-carboxyethyl group.

UniProtKB Entries (1)

Q9LCV9
CEAS_STRCL
Streptomyces clavuligerus
N(2)-(2-carboxyethyl)arginine synthase

PDB Structure

PDB 1UPC
External Links
Method X-RAY DIFFRACTION
Organism
Primary Citation
Crystal Structure and Mechanistic Implications of N2-(2-Carboxyethyl)Arginine Synthase, the First Enzyme in the Clavulanic Acid Biosynthesis Pathway
Caines, M.E.C., Elkins, J.M., Hewitson, K.S., Schofield, C.J.
J.Biol.Chem.