CATH Classification

Domain Context

CATH Clusters

Superfamily B-lactam Antibiotic, Isopenicillin N Synthase; Chain
Functional Family

Enzyme Information

1.14.20.1
Deacetoxycephalosporin-C synthase.
based on mapping to UniProt P18548
Penicillin N + 2-oxoglutarate + O(2) = deacetoxycephalosporin C + succinate + CO(2) + H(2)O.
-!- Forms part of the penicillin biosynthesis pathway.

UniProtKB Entries (1)

P18548
CEFE_STRC2
Streptomyces clavuligerus ATCC 27064
Deacetoxycephalosporin C synthase

PDB Structure

PDB 1UO9
External Links
Method X-RAY DIFFRACTION
Organism
Primary Citation
The Structural Basis of Cephalosporin Formation in a Mononuclear Ferrous Enzyme
Valegard, K., Terwisscha Van Scheltinga, A.C., Dubus, A., Ranghino, G., Oster, L.M., Hajdu, J., Andersson, I.
Nat.Struct.Mol.Biol.