CATH Domain 1uliE01

CATH Classification

Level	CATH Code	Description
	3	Alpha Beta
	3.90	Alpha-Beta Complex
	3.90.380	Naphthalene 1,2-dioxygenase Alpha Subunit; Chain A, domain 1
	3.90.380.10	Naphthalene 1,2-dioxygenase Alpha Subunit; Chain A, domain 1

Domain Context

CATH Clusters

Superfamily	Naphthalene 1,2-dioxygenase Alpha Subunit; Chain A, domain 1
Functional Family

Enzyme Information

1.14.12.18

Biphenyl 2,3-dioxygenase.

based on mapping to UniProt Q53122

Biphenyl + NADH + O(2) = (1S,2R)-3-phenylcyclohexa-3,5-diene-1,2-diol + NAD(+).

-!- The enzyme from Burkholderia fungorum strain LB400 (previously Pseudomonas sp.) is part of a multicomponent system composed of an NADH:ferredoxin oxidoreductase (FAD cofactor), a [2Fe-2S] Rieske-type ferredoxin, and a terminal oxygenase that contains a [2Fe-2S] Rieske- type iron-sulfur cluster and a catalytic mononuclear nonheme iron center. -!- Chlorine-substituted biphenyls can also act as substrates. -!- Similar to the three-component enzyme systems EC 1.14.12.3 and EC 1.14.12.11.

UniProtKB Entries (1)

Q53122

BPHA1_RHOJR

Rhodococcus jostii RHA1

Biphenyl 2,3-dioxygenase subunit alpha

PDB Structure

PDB	1ULI
External Links	PDBSum Proteopedia
Method	X-RAY DIFFRACTION
Organism	Rhodococcus
Primary Citation	Crystal Structure of the Terminal Oxygenase Component of Biphenyl Dioxygenase Derived from Rhodococcus sp. Strain RHA1 Furusawa, Y., Nagarajan, V., Tanokura, M., Masai, E., Fukuda, M., Senda, T. J.Mol.Biol.