CATH Classification

Domain Context

CATH Clusters

Superfamily Beta Polymerase, domain 2
Functional Family tRNA nucleotidyltransferase, CCA-adding enzyme

Enzyme Information
CCA tRNA nucleotidyltransferase.
based on mapping to UniProt O28126
A tRNA precursor + 2 CTP + ATP = a tRNA with a 3' CCA end + 3 diphosphate.
-!- The acylation of all tRNAs with an amino acid occurs at the terminal ribose of a 3' CCA sequence. -!- The CCA sequence is added to the tRNA precursor by stepwise nucleotide addition performed by a single enzyme that is ubiquitous in all living organisms. -!- Although the enzyme has the option of releasing the product after each addition, it prefers to stay bound to the product and proceed with the next addition. -!- Formerly EC and EC

UniProtKB Entries (1)

Archaeoglobus fulgidus DSM 4304
CCA-adding enzyme

PDB Structure

External Links
Organism Escherichia
Primary Citation
Divergent evolutions of trinucleotide polymerization revealed by an archaeal CCA-adding enzyme structure.
Okabe, M., Tomita, K., Ishitani, R., Ishii, R., Takeuchi, N., Arisaka, F., Nureki, O., Yokoyama, S.
Embo J.