CATH Classification

Domain Context

CATH Clusters

Superfamily 3.40.1280.10
Functional Family tRNA (Guanine-N(1)-)-methyltransferase

Enzyme Information

2.1.1.228
tRNA (guanine(37)-N(1))-methyltransferase.
based on mapping to UniProt P43912
S-adenosyl-L-methionine + guanine(37) in tRNA = S-adenosyl-L-homocysteine + N(1)-methylguanine(37) in tRNA.
-!- This enzyme is important for the maintenance of the correct reading frame during translation. -!- Unlike TrmD from Escherichia coli, which recognizes the G(36)pG(37) motif preferentially, the human enzyme (encoded by TRMT5) also methylates inosine at position 37. -!- Formerly EC 2.1.1.31.

UniProtKB Entries (1)

P43912
TRMD_HAEIN
Haemophilus influenzae Rd KW20
TRNA (guanine-N(1)-)-methyltransferase

PDB Structure

PDB 1UAM
External Links
Method X-RAY DIFFRACTION
Organism Escherichia
Primary Citation
Crystal structure of tRNA(m(1)G37)methyltransferase: insights into tRNA recognition
Ahn, H.J., Kim, H.-W., Yoon, H.-J., Lee, B.I., Suh, S.W., Yang, J.K.
EMBO J.