CATH Classification

Domain Context

CATH Clusters

Superfamily 3.40.1190.20
Functional Family

Enzyme Information

2.7.1.147
ADP-specific glucokinase.
based on mapping to UniProt Q9V2Z6
ADP + D-glucose = AMP + D-glucose 6-phosphate.
-!- The enzyme from Pyrococcus furiosus is highly specific for D-glucose; there is some activity with 2-deoxy-D-glucose, but no activity with D-fructose, D-mannose or D-galactose as the substrate. -!- No activity is detected when ADP is replaced by ATP, GDP, phosphoenolpyruvate, diphosphate or polyphosphate.

UniProtKB Entries (1)

Q9V2Z6
GLKA_PYRFU
Pyrococcus furiosus DSM 3638
ADP-dependent glucokinase

PDB Structure

PDB 1UA4
External Links
Method X-RAY DIFFRACTION
Organism Escherichia
Primary Citation
Crystal structure of an ADP-dependent glucokinase from Pyrococcus furiosus: implications for a sugar-induced conformational change in ADP-dependent kinase
Ito, S., Fushinobu, S., Jeong, J.J., Yoshioka, I., Koga, S., Shoun, H., Wakagi, T.
J.Mol.Biol.