CATH Classification

Domain Context

CATH Clusters

Superfamily NAD(P)-binding Rossmann-like Domain
Functional Family L-lactate dehydrogenase

Enzyme Information

1.1.1.27
L-lactate dehydrogenase.
based on mapping to UniProt Q27743
(S)-lactate + NAD(+) = pyruvate + NADH.
-!- Also oxidizes other (S)-2-hydroxymonocarboxylic acids. -!- NADP(+) acts, more slowly, with the animal, but not the bacterial, enzyme.

UniProtKB Entries (1)

Q27743
LDH_PLAFD
Plasmodium falciparum CDC/Honduras
L-lactate dehydrogenase

PDB Structure

PDB 1U5A
External Links
Method X-RAY DIFFRACTION
Organism Escherichia
Primary Citation
Mapping the binding site for gossypol-like inhibitors of Plasmodium falciparum lactate dehydrogenase.
Conners, R., Schambach, F., Read, J., Cameron, A., Sessions, R.B., Vivas, L., Easton, A., Croft, S.L., Brady, R.L.
Mol.Biochem.Parasitol.