CATH Classification

Domain Context

CATH Clusters

Superfamily Type I PLP-dependent aspartate aminotransferase-like (Major domain)
Functional Family Aspartate aminotransferase

Enzyme Information

2.6.1.88
Methionine transaminase.
based on mapping to UniProt P77806
L-methionine + a 2-oxo acid = 2-oxo-4-methylthiobutanoate + an L-amino acid.
-!- The enzyme is most active with L-methionine. -!- It participates in the L-methionine salvage pathway from S-methyl- 5'-thioadenosine, a by-product of polyamine biosynthesis. -!- The enzyme from the bacterium Klebsiella pneumoniae can use several different amino acids as amino donor, with aromatic amino acids being the most effective. -!- The enzyme from the plant Arabidopsis thaliana is also a part of the chain elongation pathway in the biosynthesis of methionine-derived glucosinolates.

UniProtKB Entries (1)

P77806
YBDL_ECOLI
Escherichia coli K-12
Methionine aminotransferase

PDB Structure

PDB 1U08
External Links
Method X-RAY DIFFRACTION
Organism Escherichia
Primary Citation
Crystal structure and reactivity of YbdL from Escherichia coli identify a methionine aminotransferase function
Dolzan, M., Johansson, K., Roig-Zamboni, V., Campanacci, V., Tegoni, M., Schneider, G., Cambillau, C.
FEBS Lett.