CATH Classification
| Level | CATH Code | Description |
|---|---|---|
|
3 | Alpha Beta |
|
3.50 | 3-Layer(bba) Sandwich |
|
3.50.50 | FAD/NAD(P)-binding domain |
|
3.50.50.60 | FAD/NAD(P)-binding domain |
Domain Context
CATH Clusters
| Superfamily | FAD/NAD(P)-binding domain |
| Functional Family | Glutathione reductase |
Enzyme Information
| 1.8.1.12 |
Trypanothione-disulfide reductase.
based on mapping to UniProt P39040
Trypanothione + NADP(+) = trypanothione disulfide + NADPH.
-!- Trypanothione disulfide is the oxidized form of N(1),N(8)- bis(glutathionyl)-spermidine from the insect-parasitic trypanosomatid Crithidia fasciculata. -!- The activity is dependent on a redox-active cystine at the active center (cf. EC 1.8.1.7). -!- Formerly EC 1.6.4.8.
|
UniProtKB Entries (1)
| P39040 |
TYTR_CRIFA
Crithidia fasciculata
Trypanothione reductase
|
PDB Structure
| PDB | 1TYP |
| External Links | |
| Method | X-RAY DIFFRACTION |
| Organism | |
| Primary Citation |
Substrate interactions between trypanothione reductase and N1-glutathionylspermidine disulphide at 0.28-nm resolution.
Eur.J.Biochem.
|