CATH Classification

Domain Context

CATH Clusters

Superfamily Dimeric alpha+beta barrel.
Functional Family

Enzyme Information

4.2.1.154
Tetracenomycin F2 cyclase.
based on mapping to UniProt P39890
Tetracenomycin F2 = tetracenomycin F1 + H(2)O.
-!- The enzyme is involved in biosynthesis of the anthracycline antibiotic tetracenomycin C by the bacterium Streptomyces glaucescens.

UniProtKB Entries (1)

P39890
TCMI_STRGA
Streptomyces glaucescens
Tetracenomycin F2 cyclase

PDB Structure

PDB 1TUW
External Links
Method X-RAY DIFFRACTION
Organism Escherichia
Primary Citation
Structural and functional analysis of tetracenomycin F2 cyclase from Streptomyces glaucescens. A type II polyketide cyclase.
Thompson, T.B., Katayama, K., Watanabe, K., Hutchinson, C.R., Rayment, I.
J.Biol.Chem.