CATH Classification

Domain Context

CATH Clusters

Superfamily 1.20.1050.10
Functional Family Glutathione S-transferase P 1

Enzyme Information

2.5.1.18
Glutathione transferase.
based on mapping to UniProt P46427
RX + glutathione = HX + R-S-glutathione.
-!- A group of enzymes of broad specificity. -!- R may be an aliphatic, aromatic or heterocyclic group; X may be a sulfate, nitrile or halide group. -!- Also catalyzes the addition of aliphatic epoxides and arene oxides to glutathione, the reduction of polyol nitrate by glutathione to polyol and nitrile, certain isomerization reactions and disulfide interchange. -!- Formerly EC 1.8.6.1, EC 2.5.1.12, EC 2.5.1.13, EC 2.5.1.14 and EC 4.4.1.7.

UniProtKB Entries (1)

P46427
GSTP_ONCVO
Onchocerca volvulus
Glutathione S-transferase 2

PDB Structure

PDB 1TU7
External Links
Method X-RAY DIFFRACTION
Organism Escherichia
Primary Citation
Structure of the Major Cytosolic Glutathione S-Transferase from the Parasitic Nematode Onchocerca volvulus
Perbandt, M., Hoppner, J., Betzel, C., Walter, R.D., Liebau, E.
J.Biol.Chem.