CATH Classification

Domain Context

CATH Clusters

Superfamily Cysteine proteinases
Functional Family

Enzyme Information

3.4.22.38
Cathepsin K.
based on mapping to UniProt P43235
Broad proteolytic activity. With small-molecule substrates and inhibitors, the major determinant of specificity is P2, which is preferably Leu, Met > Phe, and not Arg.
-!- Prominently expressed in mammalian osteoclasts, and believed to play a role in bone resorption. -!- Belongs to peptidase family C1.

UniProtKB Entries (1)

P43235
CATK_HUMAN
Homo sapiens
Cathepsin K

PDB Structure

PDB 1TU6
External Links
Method X-RAY DIFFRACTION
Organism Spodoptera
Primary Citation
Potent and selective P2-P3 ketoamide inhibitors of cathepsin K with improved pharmacokinetic properties via favorable P1', P1, and/or P3 substitutions
Barrett, D.G., Catalano, J.G., Deaton, D.N., Hassell, A.M., Long, S.T., Miller, A.B., Miller, L.R., Shewchuk, L.M., Wells-Knecht, K.J., Willard, D.H., Wright, L.L.
BIOORG.MED.CHEM.LETT.