CATH Domain 1tt5B02

CATH Classification

Level	CATH Code	Description
	1	Mainly Alpha
	1.10	Orthogonal Bundle
	1.10.10	Arc Repressor Mutant, subunit A
	1.10.10.520	Ubiquitin activating enzymes (Uba3). Chain: B, domain 2

Domain Context

CATH Clusters

Superfamily	Ubiquitin activating enzymes (Uba3). Chain: B, domain 2
Functional Family	NEDD8-activating enzyme E1 catalytic subunit

Enzyme Information

6.2.1.-

Acid--thiol ligases.

based on mapping to UniProt Q8TBC4

UniProtKB Entries (1)

UBA3_HUMAN

Homo sapiens

NEDD8-activating enzyme E1 catalytic subunit

PDB Structure

PDB	1TT5
External Links	PDBSum Proteopedia
Method	X-RAY DIFFRACTION
Organism	Escherichia
Primary Citation	A unique E1-E2 interaction required for optimal conjugation of the ubiquitin-like protein NEDD8. Huang, D.T., Miller, D.W., Mathew, R., Cassell, R., Holton, J.M., Roussel, M.F., Schulman, B.A. Nat.Struct.Mol.Biol.