CATH Classification

Domain Context

CATH Clusters

Superfamily Trypsin-like serine proteases
Functional Family Anionic trypsin

Enzyme Information

3.4.21.4
Trypsin.
based on mapping to UniProt P00763
Preferential cleavage: Arg-|-Xaa, Lys-|-Xaa.
-!- Belongs to peptidase family S1. -!- Formerly EC 3.4.4.4.

UniProtKB Entries (1)

P00763
TRY2_RAT
Rattus norvegicus
Anionic trypsin-2

PDB Structure

PDB 1TRM
External Links
Method X-RAY DIFFRACTION
Organism
Primary Citation
The three-dimensional structure of Asn102 mutant of trypsin: role of Asp102 in serine protease catalysis.
Sprang, S., Standing, T., Fletterick, R.J., Stroud, R.M., Finer-Moore, J., Xuong, N.H., Hamlin, R., Rutter, W.J., Craik, C.S.
Science