CATH Classification

Domain Context

CATH Clusters

Superfamily Trypsin-like serine proteases
Functional Family Prothrombin

Enzyme Information

3.4.21.5
Thrombin.
based on mapping to UniProt P00734
Selective cleavage of Arg-|-Gly bonds in fibrinogen to form fibrin and release fibrinopeptides A and B.
-!- More selective than trypsin and plasmin. -!- Belongs to peptidase family S1. -!- Formerly EC 3.4.4.13.

UniProtKB Entries (1)

P00734
THRB_HUMAN
Homo sapiens
Prothrombin

PDB Structure

PDB 1TQ0
External Links
Method X-RAY DIFFRACTION
Organism Cricetulus
Primary Citation
The anticoagulant thrombin mutant W215A/E217A has a collapsed primary specificity pocket
Pineda, A.O., Chen, Z.-W., Caccia, S., Cantwell, A.M., Savvides, S.N., Waksman, G., Mathews, F.S., Di Cera, E.
J.Biol.Chem.