CATH Classification

Domain Context

CATH Clusters

Superfamily Laminin
Functional Family Tissue-type plasminogen activator

Enzyme Information

3.4.21.68
T-plasminogen activator.
based on mapping to UniProt P00750
Specific cleavage of Arg-|-Val bond in plasminogen to form plasmin.
-!- From a wide variety of mammalian tissues, especially endothelial cells. -!- Secreted as a single chain precursor which is cleaved to a two-chain form by plasmin. -!- Activity is considerably enhanced by fibrin. -!- Belongs to peptidase family S1. -!- Formerly EC 3.4.21.31 and EC 3.4.99.26.

UniProtKB Entries (1)

P00750
TPA_HUMAN
Homo sapiens
Tissue-type plasminogen activator

PDB Structure

PDB 1TPG
External Links
Method SOLUTION NMR
Organism Saccharomyces
Primary Citation
The solution structure and backbone dynamics of the fibronectin type I and epidermal growth factor-like pair of modules of tissue-type plasminogen activator.
Smith, B.O., Downing, A.K., Driscoll, P.C., Dudgeon, T.J., Campbell, I.D.
Structure