CATH Classification

Domain Context

CATH Clusters

Superfamily Type I PLP-dependent aspartate aminotransferase-like (Major domain)
Functional Family Aspartate aminotransferase

Enzyme Information

2.6.1.1
Aspartate transaminase.
based on mapping to UniProt P00509
L-aspartate + 2-oxoglutarate = oxaloacetate + L-glutamate.
-!- Also acts on L-tyrosine, L-phenylalanine and L-tryptophan. -!- This activity can be formed from EC 2.6.1.57 by controlled proteolysis.

UniProtKB Entries (1)

P00509
AAT_ECOLI
Escherichia coli K-12
Aspartate aminotransferase

PDB Structure

PDB 1TOK
External Links
Method X-RAY DIFFRACTION
Organism Escherichia
Primary Citation
Narrowing substrate specificity in a directly evolved enzyme: the A293D mutant of aspartate aminotransferase
Chow, M.A., McElroy, K.E., Corbett, K.D., Berger, J.M., Kirsch, J.F.
Biochemistry