CATH Classification

Domain Context

CATH Clusters

Superfamily 3.40.50.970
Functional Family Transketolase

Enzyme Information

2.2.1.1
Transketolase.
based on mapping to UniProt P23254
Sedoheptulose 7-phosphate + D-glyceraldehyde 3-phosphate = D-ribose 5-phosphate + D-xylulose 5-phosphate.
-!- Wide specificity for both reactants, e.g. converts hydroxypyruvate and R-CHO into CO(2) and R-CHOH-CO-CH(2)OH. -!- The enzyme from the bacterium Alcaligenes faecalis shows high activity with D-erythrose 4-phosphate as acceptor.

UniProtKB Entries (1)

P23254
TKT1_YEAST
Saccharomyces cerevisiae S288C
Transketolase 1

PDB Structure

PDB 1TKC
External Links
Method X-RAY DIFFRACTION
Organism
Primary Citation
Specificity of coenzyme binding in thiamin diphosphate-dependent enzymes. Crystal structures of yeast transketolase in complex with analogs of thiamin diphosphate.
Konig, S., Schellenberger, A., Neef, H., Schneider, G.
J.Biol.Chem.