CATH Classification

Domain Context

CATH Clusters

Superfamily Taq DNA Polymerase; Chain T, domain 4
Functional Family DNA-directed DNA polymerase

Enzyme Information

3.1.11.-
Exodeoxyribonucleases producing 5'-phosphomonoesters.
based on mapping to UniProt P00581
2.7.7.7
DNA-directed DNA polymerase.
based on mapping to UniProt P00581
Deoxynucleoside triphosphate + DNA(n) = diphosphate + DNA(n+1).
-!- Catalyzes DNA-template-directed extension of the 3'-end of a DNA strand by one nucleotide at a time. -!- Cannot initiate a chain de novo. -!- Requires a primer which may be DNA or RNA. -!- See also EC 2.7.7.49.

UniProtKB Entries (2)

P0AA25
THIO_ECOLI
Escherichia coli K-12
Thioredoxin 1
P00581
DPOL_BPT7
Enterobacteria phage T7
DNA-directed DNA polymerase

PDB Structure

PDB 1TK8
External Links
Method X-RAY DIFFRACTION
Organism Escherichia
Primary Citation
Structural basis for the dual coding potential of 8-oxoguanosine by a high-fidelity DNA polymerase.
Brieba, L.G., Eichman, B.F., Kokoska, R.J., Doublie, S., Kunkel, T.A., Ellenberger, T.
Embo J.