CATH Classification

Domain Context

CATH Clusters

Superfamily Peptidase S8/S53 domain
Functional Family

Enzyme Information

3.4.21.66
Thermitase.
based on mapping to UniProt P04072
Hydrolysis of proteins, including collagen.
-!- From Thermoactinomyces vulgaris containing a single Cys, near the active site His, and inhibited by p-mercuribenzoate. -!- The N-terminal extension of the polypeptide chain relative to subtilisin contributes to calcium-binding and the high thermostability. -!- The amino acid composition and properties of the thermostable enzyme from Streptomyces rectus var. proteolyticus are closely similar. -!- Belongs to peptidase family S8. -!- Formerly EC 3.4.4.16.

UniProtKB Entries (2)

P04072
THET_THEVU
Thermoactinomyces vulgaris
Thermitase
P01051
ICIC_HIRME
Hirudo medicinalis
Eglin C

PDB Structure

PDB 1TEC
External Links
Method X-RAY DIFFRACTION
Organism
Primary Citation
Crystallographic refinement by incorporation of molecular dynamics: thermostable serine protease thermitase complexed with eglin c.
Gros, P., Fujinaga, M., Dijkstra, B.W., Kalk, K.H., Hol, W.G.
Acta Crystallogr.,Sect.B