CATH Classification

Domain Context

CATH Clusters

Superfamily Thymidylate synthase/dCMP hydroxymethylase domain
Functional Family

Enzyme Information

2.1.1.45
Thymidylate synthase.
based on mapping to UniProt P00469
5,10-methylenetetrahydrofolate + dUMP = dihydrofolate + dTMP.

UniProtKB Entries (1)

P00469
TYSY_LACCA
Lactobacillus casei
Thymidylate synthase

PDB Structure

PDB 1TDB
External Links
Method X-RAY DIFFRACTION
Organism
Primary Citation
Structures of thymidylate synthase with a C-terminal deletion: role of the C-terminus in alignment of 2'-deoxyuridine 5'-monophosphate and 5,10-methylenetetrahydrofolate.
Perry, K.M., Carreras, C.W., Chang, L.C., Santi, D.V., Stroud, R.M.
Biochemistry