CATH Domain 1tbnA00
|3.30.60||Wheat Germ Agglutinin (Isolectin 2); domain 1|
|Functional Family||Protein kinase C|
Protein kinase C.
based on mapping to UniProt P63319
ATP + a protein = ADP + a phosphoprotein.
-!- A family of serine- and threonine-specific protein kinases that depend on lipids for activity. -!- They can be activated by calcium but have a requirement for the second messenger diacylglycerol. -!- Members of this group of enzymes phosphorylate a wide variety of protein targets and are known to be involved in diverse cell- signaling pathways. -!- Members of the protein kinase C family also serve as major receptors for phorbol esters, a class of tumor promoters. -!- Formerly EC 188.8.131.52.
UniProtKB Entries (1)
Protein kinase C gamma type
NMR structure of a protein kinase C-gamma phorbol-binding domain and study of protein-lipid micelle interactions.