CATH Classification

Domain Context

CATH Clusters

Superfamily Pancreatic trypsin inhibitor Kunitz domain
Functional Family Amyloid beta A4 protein

Enzyme Information

UniProtKB Entries (2)

P00760
TRY1_BOVIN
Bos taurus
Cationic trypsin
P05067
A4_HUMAN
Homo sapiens
Amyloid-beta precursor protein

PDB Structure

PDB 1TAW
External Links
Method X-RAY DIFFRACTION
Organism Escherichia
Primary Citation
Crystal structures of bovine chymotrypsin and trypsin complexed to the inhibitor domain of Alzheimer's amyloid beta-protein precursor (APPI) and basic pancreatic trypsin inhibitor (BPTI): engineering of inhibitors with altered specificities.
Scheidig, A.J., Hynes, T.R., Pelletier, L.A., Wells, J.A., Kossiakoff, A.A.
Protein Sci.