CATH Classification

Domain Context

CATH Clusters

Superfamily MoaB/Mog-like domain
Functional Family Molybdopterin molybdenumtransferase

Enzyme Information

2.7.7.75
Molybdopterin adenylyltransferase.
based on mapping to UniProt Q03555
ATP + molybdopterin = diphosphate + adenylyl-molybdopterin.
-!- Catalyzes the activation of molybdopterin for molybdenum insertion. -!- In eukaryotes, this reaction is catalyzed by the C-terminal domain of a fusion protein that also includes molybdopterin molybdotransferase (EC 2.10.1.1). -!- The reaction requires a divalent cation such as Mg(2+) or Mn(2+). -!- Catalyzes the activation of molybdopterin for molybdenum insertion. -!- In eukaryotes, this reaction is catalyzed by the C-terminal domain of a fusion protein that also includes EC 2.10.1.1. -!- Formerly EC 2.7.7.n5.
2.10.1.1
Molybdopterin molybdotransferase.
based on mapping to UniProt Q03555
Adenylyl-molybdopterin + molybdate = molybdenum cofactor + AMP.
-!- Catalyzes the insertion of molybdenum into the ene-dithiol group of molybdopterin. -!- In eukaryotes this reaction is catalyzed by the N-terminal domain of a fusion protein whose C-terminal domain catalyzes EC 2.7.7.75.

UniProtKB Entries (1)

P20781
GLRB_RAT
Rattus norvegicus
Glycine receptor subunit beta

PDB Structure

PDB 1T3E
External Links
Method X-RAY DIFFRACTION
Organism Escherichia
Primary Citation
Structural basis of dynamic glycine receptor clustering by gephyrin
Sola, M., Bavro, V.N., Timmins, J., Franz, T., Ricard-Blum, S., Schoehn, G., Ruigrok, R.W.H., Paarmann, I., Saiyed, T., O'Sullivan, G.A., Schmitt, B., Betz, H., Weissenhorn, W.
Embo J.