CATH Classification

Domain Context

CATH Clusters

Superfamily NAD(P)-binding Rossmann-like Domain
Functional Family L-lactate dehydrogenase A chain

Enzyme Information

1.1.1.27
L-lactate dehydrogenase.
based on mapping to UniProt P07195
(S)-lactate + NAD(+) = pyruvate + NADH.
-!- Also oxidizes other (S)-2-hydroxymonocarboxylic acids. -!- NADP(+) acts, more slowly, with the animal, but not the bacterial, enzyme.

UniProtKB Entries (1)

P07195
LDHB_HUMAN
Homo sapiens
L-lactate dehydrogenase B chain

PDB Structure

PDB 1T2F
External Links
Method X-RAY DIFFRACTION
Organism Escherichia
Primary Citation
Identification and Activity of a Series of Azole-based Compounds with Lactate Dehydrogenase-directed Anti-malarial Activity.
Cameron, A., Read, J., Tranter, R., Winter, V.J., Sessions, R.B., Brady, R.L., Vivas, L., Easton, A., Kendrick, H., Croft, S.L., Barros, D., Lavandera, J.L., Martin, J.J., Risco, F., Garcia-Ochoa, S., Gamo, F.J., Sanz, L., Leon, L., Ruiz, J.R., Gabarro, R., Mallo, A., De Las Heras, F.G.
J.Biol.Chem.