CATH Classification

Domain Context

CATH Clusters

Superfamily 2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase
Functional Family 2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase

Enzyme Information

4.6.1.12
2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase.
based on mapping to UniProt Q8EBR3
2-phospho-4-(cytidine 5'-diphospho)-2-C-methyl-D-erythritol = 2-C-methyl- D-erythritol 2,4-cyclodiphosphate + CMP.
-!- Forms part of an alternative nonmevalonate pathway for terpenoid biosynthesis.

UniProtKB Entries (1)

Q8EBR3
ISPF_SHEON
Shewanella oneidensis MR-1
2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase

PDB Structure

PDB 1T0A
External Links
Method X-RAY DIFFRACTION
Organism Escherichia
Primary Citation
Structure of 2C-methyl-D-erythritol-2,4-cyclodiphosphate synthase from Shewanella oneidensis at 1.6 A: identification of farnesyl pyrophosphate trapped in a hydrophobic cavity.
Ni, S., Robinson, H., Marsing, G.C., Bussiere, D.E., Kennedy, M.A.
Acta Crystallogr.,Sect.D