CATH Classification

Domain Context

CATH Clusters

Superfamily Isopropylmalate Dehydrogenase
Functional Family Isocitrate dehydrogenase [NADP]

Enzyme Information

1.1.1.42
Isocitrate dehydrogenase (NADP(+)).
based on mapping to UniProt O75874
Isocitrate + NADP(+) = 2-oxoglutarate + CO(2) + NADPH.
-!- Unlike EC 1.1.1.41, oxalosuccinate can be used as a substrate. -!- In eukaryotes, isocitrate dehydrogenase exists in two forms: an NAD(+)-linked enzyme found only in mitochondria and displaying allosteric properties, and a non-allosteric, NADP(+)-linked enzyme that is found in both mitochondria and cytoplasm. -!- The enzyme from some species can also use NAD(+) but much more slowly.

UniProtKB Entries (1)

O75874
IDHC_HUMAN
Homo sapiens
Isocitrate dehydrogenase [NADP] cytoplasmic

PDB Structure

PDB 1T09
External Links
Method X-RAY DIFFRACTION
Organism Escherichia
Primary Citation
Structures of human cytosolic NADP-dependent isocitrate dehydrogenase reveal a novel self-regulatory mechanism of activity
Xu, X., Zhao, J., Xu, Z., Peng, B., Huang, Q., Arnold, E., Ding, J.
J.Biol.Chem.