CATH Classification

Domain Context

CATH Clusters

Superfamily NAD(P)-binding Rossmann-like Domain
Functional Family 3-hydroxyacyl-CoA dehydrogenase type-2

Enzyme Information

1.1.1.178
3-hydroxy-2-methylbutyryl-CoA dehydrogenase.
based on mapping to UniProt Q99714
(2S,3S)-3-hydroxy-2-methylbutanoyl-CoA + NAD(+) = 2-methylacetoacetyl-CoA + NADH.
-!- Also acts, more slowly, on (2S,3S)-2-hydroxy-3-methylpentanoyl-CoA.
1.1.1.51
3(or 17)-beta-hydroxysteroid dehydrogenase.
based on mapping to UniProt Q99714
Testosterone + NAD(P)(+) = androst-4-ene-3,17-dione + NAD(P)H.
-!- Also acts on other 3-beta- or 17-beta-hydroxysteroids (cf. EC 1.1.1.209).
1.1.1.35
3-hydroxyacyl-CoA dehydrogenase.
based on mapping to UniProt Q99714
(S)-3-hydroxyacyl-CoA + NAD(+) = 3-oxoacyl-CoA + NADH.
-!- Also oxidizes S-3-hydroxyacyl-N-acylthioethanolamine and S-3- hydroxyacylhydrolipoate. -!- Some enzymes act, more slowly, with NADP(+). -!- Broad specificity to acyl chain-length (cf. EC 1.1.1.211).

UniProtKB Entries (1)

Q99714
HCD2_HUMAN
Homo sapiens
3-hydroxyacyl-CoA dehydrogenase type-2

PDB Structure

PDB 1SO8
External Links
Method X-RAY DIFFRACTION
Organism Escherichia
Primary Citation
ABAD directly links Abeta to mitochondrial toxicity in Alzheimer's disease.
Lustbader, J.W., Cirilli, M., Lin, C., Xu, H.W., Takuma, K., Wang, N., Caspersen, C., Chen, X., Pollak, S., Chaney, M., Trinchese, F., Gunn-Moore, F., Lue, L.F., Walker, D.G., Kuppusamy, P., Zewier, Z.L., Arancio, O., Stern, D., Yan, S.S., Wu, H.
Science