CATH Classification

Domain Context

CATH Clusters

Superfamily Trypsin-like serine proteases
Functional Family Anionic trypsin-2

Enzyme Information

3.4.21.4
Trypsin.
based on mapping to UniProt P00763
Preferential cleavage: Arg-|-Xaa, Lys-|-Xaa.
-!- Belongs to peptidase family S1. -!- Formerly EC 3.4.4.4.

UniProtKB Entries (2)

P23827
ECOT_ECOLI
Escherichia coli K-12
Ecotin
P00763
TRY2_RAT
Rattus norvegicus
Anionic trypsin-2

PDB Structure

PDB 1SLU
External Links
Method X-RAY DIFFRACTION
Organism Escherichia
Primary Citation
X-ray structures of a designed binding site in trypsin show metal-dependent geometry.
Brinen, L.S., Willett, W.S., Craik, C.S., Fletterick, R.J.
Biochemistry