CATH Domain 1siqA03
|1.20.140||Butyryl-CoA Dehydrogenase, subunit A; domain 3|
|220.127.116.11||Butyryl-CoA Dehydrogenase, subunit A, domain 3|
|Superfamily||Butyryl-CoA Dehydrogenase, subunit A, domain 3|
|Functional Family||Glutaryl-CoA dehydrogenase, mitochondrial|
Glutaryl-CoA dehydrogenase (ETF).
based on mapping to UniProt Q92947
Glutaryl-CoA + electron-transfer flavoprotein = crotonyl-CoA + CO(2) + reduced electron-transfer flavoprotein.
-!- The enzyme catalyzes the oxidation of glutaryl-CoA to glutaconyl-CoA (which remains bound to the enzyme), and the decarboxylation of the latter to crotonyl-CoA (cf. EC 18.104.22.168). -!- FAD is the electron acceptor in the oxidation of the substrate, and its reoxidation by electron-transfer flavoprotein completes the catalytic cycle. -!- The anaerobic, sulfate-reducing bacterium Desulfococcus multivorans contains two glutaryl-CoA dehydrogenases: a decarboxylating enzyme (this entry), and a non-decarboxylating enzyme that only catalyzes the oxidation to glutaconyl-CoA (EC 22.214.171.124). -!- Formerly EC 126.96.36.199.
UniProtKB Entries (1)
Glutaryl-CoA dehydrogenase, mitochondrial
Crystal Structures of Human Glutaryl-CoA Dehydrogenase with and without an Alternate Substrate: Structural Bases of Dehydrogenation and Decarboxylation Reactions