CATH Classification

Domain Context

CATH Clusters

Superfamily TruD, insertion domain
Functional Family tRNA pseudouridine synthase D

Enzyme Information

5.4.99.27
tRNA pseudouridine(13) synthase.
based on mapping to UniProt Q57261
tRNA uridine(13) = tRNA pseudouridine(13).
-!- Pseudouridine synthase PusS from Escherichia coli specifically acts on uridine(13) in tRNA. -!- The Pus7 protein from Saccharomyces cerevisiae is a multisite- multisubstrate pseudouridine synthase that is able to modify uridine(13) in several yeast tRNAs, uridine(35) in the pre-tRNA(Tyr), uridine(35) in U2 small nuclear RNA, and uridine(50) in 5S rRNA.

UniProtKB Entries (1)

Q57261
TRUD_ECOLI
Escherichia coli K-12
TRNA pseudouridine synthase D

PDB Structure

PDB 1SB7
External Links
Method X-RAY DIFFRACTION
Organism Escherichia
Primary Citation
Crystal structure of the highly divergent pseudouridine synthase TruD reveals a circular permutation of a conserved fold.
Hoang, C., Ferre-D'Amare, A.R.
Rna