CATH Classification
| Level | CATH Code | Description |
|---|---|---|
|
3 | Alpha Beta |
|
3.30 | 2-Layer Sandwich |
|
3.30.450 | Beta-Lactamase |
|
3.30.450.20 | PAS domain |
Domain Context
CATH Clusters
| Superfamily | PAS domain |
| Functional Family | Oxygen sensor protein DosP |
Enzyme Information
| 3.1.4.52 |
Cyclic-guanylate-specific phosphodiesterase.
based on mapping to UniProt P76129
Cyclic di-3',5'-guanylate + H(2)O = 5'-phosphoguanylyl(3'->5')guanosine.
-!- Inhibited by Ca(2+) and Zn(2+). -!- Linearizes cyclic di-3',5'-guanylate, the product of EC 2.7.7.65 and an allosteric activator of EC 2.4.1.12 rendering it inactive. -!- It is the balance between these two enzymes that determines the cellular level of cyclic di-3',5'-guanylate.
|
UniProtKB Entries (1)
| P76129 |
DOSP_ECOLI
Escherichia coli K-12
Oxygen sensor protein DosP
|
PDB Structure
| PDB | 1S67 |
| External Links | |
| Method | X-RAY DIFFRACTION |
| Organism | Escherichia |
| Primary Citation |
Insights into signal transduction involving PAS domain oxygen-sensing heme proteins from the X-ray crystal structure of Escherichia coli Dos heme domain (Ec DosH)
Biochemistry
|