CATH Domain 1s4eA02

CATH Classification

Level	CATH Code	Description
	3	Alpha Beta
	3.30	2-Layer Sandwich
	3.30.70	Alpha-Beta Plaits
	3.30.70.890	GHMP kinase, C-terminal domain

Domain Context

CATH Clusters

Superfamily	GHMP kinase, C-terminal domain
Functional Family	Galactokinase

Enzyme Information

2.7.1.6

Galactokinase.

based on mapping to UniProt Q9HHB6

ATP + alpha-D-galactose = ADP + alpha-D-galactose 1-phosphate.

-!- Part of the Leloir pathway for galactose metabolism. -!- The enzymes from mammals and from the bacterium Escherichia coli have no activity with N-acetyl-alpha-D-galactosamine.

UniProtKB Entries (1)

Q9HHB6

GAL1_PYRFU

Pyrococcus furiosus DSM 3638

Galactokinase

PDB Structure

PDB	1S4E
External Links	PDBSum Proteopedia
Method	X-RAY DIFFRACTION
Organism	Escherichia
Primary Citation	Substrate specificity and mechanism from the structure of Pyrococcus furiosus galactokinase Hartley, A., Glynn, S.E., Barynin, V., Baker, P.J., Sedelnikova, S.E., Verhees, C., de Geus, D., van der Oost, J., Timson, D.J., Reece, R.J., Rice, D.W. J.Mol.Biol.