CATH Classification

Domain Context

CATH Clusters

Superfamily Collagenase (Catalytic Domain)
Functional Family Thimet oligopeptidase 1

Enzyme Information

3.4.24.15
Thimet oligopeptidase.
based on mapping to UniProt P52888
Preferential cleavage of bonds with hydrophobic residues at P1, P2 and P3' and a small residue at P1' in substrates of 5 to 15 residues.
-!- Thiol compounds activate at low concentrations. -!- Belongs to peptidase family M3. -!- Formerly EC 3.4.22.19 and EC 3.4.99.31.

UniProtKB Entries (1)

P52888
THOP1_HUMAN
Homo sapiens
Thimet oligopeptidase

PDB Structure

PDB 1S4B
External Links
Method X-RAY DIFFRACTION
Organism Escherichia
Primary Citation
Crystal structure of human thimet oligopeptidase provides insight into substrate recognition, regulation, and localization
Ray, K., Hines, C.S., Coll-Rodriguez, J., Rodgers, D.W.
J.Biol.Chem.