CATH Classification
| Level | CATH Code | Description |
|---|---|---|
|
3 | Alpha Beta |
|
3.90 | Alpha-Beta Complex |
|
3.90.1760 | Adenylylcyclase toxin fold |
|
3.90.1760.10 | Anthrax toxin, edema factor, central domain |
Domain Context
CATH Clusters
| Superfamily | Anthrax toxin, edema factor, central domain |
| Functional Family |
Enzyme Information
| 4.6.1.1 |
Adenylate cyclase.
based on mapping to UniProt P40136
ATP = 3',5'-cyclic AMP + diphosphate.
-!- Also acts on dATP to form 3',5'-cyclic dAMP. -!- Requires pyruvate. -!- Activated by NAD(+) in presence of EC 2.4.2.31.
|
UniProtKB Entries (2)
| P40136 |
CYAA_BACAN
Bacillus anthracis
Calmodulin-sensitive adenylate cyclase
|
| P0DP25 |
CALM3_HUMAN
Homo sapiens
Calmodulin-3
|
PDB Structure
| PDB | 1S26 |
| External Links | |
| Method | X-RAY DIFFRACTION |
| Organism | Escherichia |
| Primary Citation |
Structure of anthrax edema factor-calmodulin-adenosine-5'-(alpha,beta-methylene)-triphosphate complex reveals an alternative mode of ATP binding to the catalytic site
Biochem.Biophys.Res.Commun.
|