CATH Domain 1rr9E01

CATH Classification

Level	CATH Code	Description
	3	Alpha Beta
	3.30	2-Layer Sandwich
	3.30.230	Ribosomal Protein S5; domain 2
	3.30.230.10

Domain Context

CATH Clusters

Superfamily	3.30.230.10
Functional Family	Lon protease

Enzyme Information

3.4.21.53

Endopeptidase La.

based on mapping to UniProt P0A9M0

Hydrolysis of proteins in presence of ATP.

-!- ATP hydrolysis is linked with peptide bond hydrolysis. -!- Vanadate inhibits both reactions. -!- A similar enzyme occurs in animal mitochondria. -!- Belongs to peptidase family S16.

UniProtKB Entries (1)

P0A9M0

LON_ECOLI

Escherichia coli K-12

Lon protease

PDB Structure

PDB	1RR9
External Links	PDBSum Proteopedia
Method	X-RAY DIFFRACTION
Organism	Escherichia
Primary Citation	The catalytic domain of Escherichia coli Lon protease has a unique fold and a Ser-Lys dyad in the active site Botos, I., Melnikov, E.E., Cherry, S., Tropea, J.E., Khalatova, A.G., Rasulova, F., Dauter, Z., Maurizi, M.R., Rotanova, T.V., Wlodawer, A., Gustchina, A. J.Biol.Chem.