CATH Classification

Domain Context

CATH Clusters

Superfamily 3.10.50.40
Functional Family Peptidylprolyl isomerase

Enzyme Information

5.2.1.8
Peptidylprolyl isomerase.
based on mapping to UniProt P27124
Peptidylproline (omega=180) = peptidylproline (omega=0).
-!- The first type of this enzyme found proved to be the protein cyclophilin, which binds the immunosuppressant cyclosporin A. -!- Other distinct families of the enzyme exist, one being FK-506 binding proteins (FKBP) and another that includes parvulin from Escherichia coli. -!- The three families are structurally unrelated and can be distinguished by being inhibited by cyclosporin A, FK-506 and 5-hydroxy-1,4-naphthoquinone, respectively.

UniProtKB Entries (1)

P27124
FKBP4_RABIT
Oryctolagus cuniculus
Peptidyl-prolyl cis-trans isomerase FKBP4

PDB Structure

PDB 1ROU
External Links
Method SOLUTION NMR
Organism Escherichia
Primary Citation
Three-dimensional structure of the immunophilin-like domain of FKBP59 in solution.
Craescu, C.T., Rouviere, N., Popescu, A., Cerpolini, E., Lebeau, M.C., Baulieu, E.E., Mispelter, J.
Biochemistry