CATH Classification

Domain Context

CATH Clusters

Superfamily 3.40.630.30
Functional Family

Enzyme Information
Acyl-homoserine-lactone synthase.
based on mapping to UniProt P33883
An acyl-[acyl-carrier-protein] + S-adenosyl-L-methionine = [acyl-carrier- protein] + S-methyl-5'-thioadenosine + an N-acyl-L-homoserine lactone.
-!- Acyl-homoserine lactones (AHLs) are produced by a number of bacterial species and are used by them to regulate the expression of virulence genes in a process known as quorum-sensing. -!- Each bacterial cell has a basal level of AHL and, once the population density reaches a critical level, it triggers AHL-signaling which, in turn, initiates the expression of particular virulence genes. -!- N-(3-oxohexanoyl)-[acyl-carrier-protein] and hexanoyl-[acyl-carrier- protein] are the best substrates. -!- The fatty-acyl substrate is derived from fatty-acid biosynthesis through acyl-[acyl-carrier-protein] rather than from fatty-acid degradation through acyl-CoA. -!- S-adenosyl-L-methionine cannot be replaced by methionine, S-adenosylhomocysteine, homoserine or homoserine lactone.

UniProtKB Entries (1)

Pseudomonas aeruginosa PAO1
Acyl-homoserine-lactone synthase

PDB Structure

External Links
Organism Escherichia
Primary Citation
Structure of the Pseudomonas aeruginosa acyl-homoserinelactone synthase LasI.
Gould, T.A., Schweizer, H.P., Churchill, M.E.