CATH Classification

Domain Context

CATH Clusters

Superfamily Ricin (A Subunit), domain 2
Functional Family

Enzyme Information

3.2.2.22
rRNA N-glycosylase.
based on mapping to UniProt P24476
Endohydrolysis of the N-glycosidic bond at one specific adenosine on the 28S rRNA.
-!- Ricin A-chain and related toxins show this activity. -!- Naked rRNA is attacked more slowly than rRNA in intact ribosomes. -!- Naked rRNA from Escherichia coli is cleaved at a corresponding position.

UniProtKB Entries (1)

P24476
RIP0_DIACA
Dianthus caryophyllus
Antiviral protein DAP-30

PDB Structure

PDB 1RL0
External Links
Method X-RAY DIFFRACTION
Organism
Primary Citation
The 1.4A structure of dianthin 30 indicates a role of surface potential at the active site of type 1 ribosome inactivating proteins
Fermani, S., Falini, G., Ripamonti, A., Polito, L., Stirpe, F., Bolognesi, A.
J.Struct.Biol.