CATH Classification

Domain Context

CATH Clusters

Superfamily Phosphorylase Kinase; domain 1
Functional Family receptor-type tyrosine-protein kinase FLT3

Enzyme Information

2.7.10.1
Receptor protein-tyrosine kinase.
based on mapping to UniProt P36888
ATP + a [protein]-L-tyrosine = ADP + a [protein]-L-tyrosine phosphate.
-!- The receptor protein-tyrosine kinases, which can be defined as having a transmembrane domain, are a large and diverse multigene family found only in metazoans. -!- In the human genome, 58 receptor-type protein-tyrosine kinases have been identified and these are distributed into 20 subfamilies. -!- Formerly EC 2.7.1.112.

UniProtKB Entries (1)

P36888
FLT3_HUMAN
Homo sapiens
Receptor-type tyrosine-protein kinase FLT3

PDB Structure

PDB 1RJB
External Links
Method X-RAY DIFFRACTION
Organism Trichoplusia
Primary Citation
The structural basis for autoinhibition of FLT3 by the juxtamembrane domain.
Griffith, J., Black, J., Faerman, C., Swenson, L., Wynn, M., Lu, F., Lippke, J., Saxena, K.
Mol.Cell