CATH Classification

Domain Context

CATH Clusters

Superfamily Vaccinia Virus protein VP39
Functional Family

Enzyme Information

2.1.1.56
mRNA (guanine-N(7)-)-methyltransferase.
based on mapping to UniProt Q8SR66
S-adenosyl-L-methionine + G(5')pppR-RNA = S-adenosyl-L-homocysteine + m(7)G(5')pppR-RNA.
-!- Adds an N(7)-methylguanine cap to mRNA. -!- The nucleoside next to the terminal guanosine may be either guanosine or adenosine.

UniProtKB Entries (1)

Q8SR66
MCES_ENCCU
Encephalitozoon cuniculi GB-M1
MRNA cap guanine-N7 methyltransferase

PDB Structure

PDB 1RI3
External Links
Method X-RAY DIFFRACTION
Organism Escherichia
Primary Citation
Structure and mechanism of mRNA cap (Guanine-n7) methyltransferase
Fabrega, C., Hausmann, S., Shen, V., Shuman, S., Lima, C.D.
Mol.Cell