CATH Classification

Domain Context

CATH Clusters

Superfamily DD-peptidase/beta-lactamase superfamily
Functional Family Beta-lactamase

Enzyme Information

3.5.2.6
Beta-lactamase.
based on mapping to UniProt P05193
A beta-lactam + H(2)O = a substituted beta-amino acid.
-!- Zinc is only requires in class-B enzymes. -!- A group of enzymes of varying specificity hydrolyzing beta-lactams; some act more rapidly on penicillins, some more rapidly on cephalosporins. -!- Formerly EC 3.5.2.8.

UniProtKB Entries (1)

P05193
AMPC_CITFR
Citrobacter freundii
Beta-lactamase

PDB Structure

PDB 1RGY
External Links
Method X-RAY DIFFRACTION
Organism Escherichia
Primary Citation
Hydrolysis of third-generation cephalosporins by class C beta-lactamases. Structures of a transition state analog of cefotoxamine in wild-type and extended spectrum enzymes.
Nukaga, M., Kumar, S., Nukaga, K., Pratt, R.F., Knox, J.R.
J.Biol.Chem.