CATH Classification

Domain Context

CATH Clusters

Superfamily Ribonuclease III domain
Functional Family Ribonuclease 3

Enzyme Information

3.1.26.3
Ribonuclease III.
based on mapping to UniProt O67082
Endonucleolytic cleavage to 5'-phosphomonoester.
-!- An endoribonuclease that cleaves double-stranded RNA molecules. -!- The cleavage can be either a single-stranded nick or double-stranded break in the RNA, depending in part upon the degree of base-pairing in the region of the cleavage site. -!- Specificity is conferred by negative determinants, i.e., the presence of certain Watson-Crick base-pairs at specific positions that strongly inhibit cleavage. -!- RNase III is involved in both rRNA processing and mRNA processing and decay.

UniProtKB Entries (1)

O67082
RNC_AQUAE
Aquifex aeolicus VF5
Ribonuclease 3

PDB Structure

PDB 1RC5
External Links
Method X-RAY DIFFRACTION
Organism Escherichia
Primary Citation
Noncatalytic Assembly of Ribonuclease III with Double-Stranded RNA.
Blaszczyk, J., Gan, J., Tropea, J.E., Court, D.L., Waugh, D.S., Ji, X.
Structure