CATH Classification

Domain Context

CATH Clusters

Superfamily Vaccinia Virus protein VP39
Functional Family Glycine N-methyltransferase

Enzyme Information

2.1.1.20
Glycine N-methyltransferase.
based on mapping to UniProt Q14749
S-adenosyl-L-methionine + glycine = S-adenosyl-L-homocysteine + sarcosine.
-!- Thought to play an important role in the regulation of methyl group metabolism in the liver and pancreas by regulating the ratio between S-adenosyl-L-methionine and S-adenosyl-L-homocysteine. -!- Inhibited by 5-methyltetrahydrofolate pentaglutamate. -!- Sarcosine, which has no physiological role, is converted back into glycine by the action of EC 1.5.8.3.

UniProtKB Entries (1)

Q14749
GNMT_HUMAN
Homo sapiens
Glycine N-methyltransferase

PDB Structure

PDB 1R74
External Links
Method X-RAY DIFFRACTION
Organism Escherichia
Primary Citation
Glycine N-methyltransferases: a comparison of the crystal structures and kinetic properties of recombinant human, mouse and rat enzymes.
Pakhomova, S., Luka, Z., Grohmann, S., Wagner, C., Newcomer, M.E.
Proteins