CATH Classification

Domain Context

CATH Clusters

Superfamily NAD(P)-binding Rossmann-like Domain
Functional Family NEDD8-activating enzyme E1 catalytic subunit, putative

Enzyme Information

6.2.1.-
Acid--thiol ligases.
based on mapping to UniProt Q8TBC4

UniProtKB Entries (1)

Q13564
ULA1_HUMAN
Homo sapiens
NEDD8-activating enzyme E1 regulatory subunit

PDB Structure

PDB 1R4N
External Links
Method X-RAY DIFFRACTION
Organism Escherichia
Primary Citation
The structure of the APPBP1-UBA3-NEDD8-ATP complex reveals the basis for selective ubiquitin-like protein activation by an E1.
Walden, H., Podgorski, M.S., Huang, D.T., Miller, D.W., Howard, R.J., Minor, D.L., Holton, J.M., Schulman, B.A.
Mol.Cell