CATH Classification

Domain Context

CATH Clusters

Superfamily Neutral endopeptidase , domain2
Functional Family Membrane metalloendopeptidase

Enzyme Information

3.4.24.11
Neprilysin.
based on mapping to UniProt P08473
Preferential cleavage of polypeptides between hydrophobic residues, particularly with Phe or Tyr at P1'.
-!- A membrane-bound glycoprotein widely distributed in animal tissues. -!- Inhibited by phosphoramidon and thiorphan. -!- Belongs to peptidase family M13.

UniProtKB Entries (1)

P08473
NEP_HUMAN
Homo sapiens
Neprilysin

PDB Structure

PDB 1R1I
External Links
Method X-RAY DIFFRACTION
Organism Saccharomyces
Primary Citation
Structural analysis of neprilysin with various specific and potent inhibitors.
Oefner, C., Roques, B.P., Fournie-Zaluski, M.C., Dale, G.E.
Acta Crystallogr.,Sect.D