CATH Classification

Domain Context

CATH Clusters

Superfamily ADP Ribosyl Cyclase; Chain A, domain 1
Functional Family

Enzyme Information

2.4.99.20
2'-phospho-ADP-ribosyl cyclase/2'-phospho-cyclic-ADP-ribose transferase.
based on mapping to UniProt P29241
NADP(+) + nicotinate = nicotinate-adenine dinucleotide phosphate + nicotinamide.
-!- This multiunctional enzyme catalyzes both the removal of nicotinamide from NADP(+), forming 2'-phospho-cyclic ADP-ribose, and the addition of nicotinate to the cyclic product, forming NAADP(+), a calcium messenger that can mobilize intracellular Ca(2+) stores and activate Ca(2+) influx to regulate a wide range of physiological processes. -!- In addition, the enzyme also catalyzes EC 3.2.2.6.
3.2.2.6
ADP-ribosyl cyclase/cyclic ADP-ribose hydrolase.
based on mapping to UniProt P29241
NAD(+) + H(2)O = ADP-D-ribose + nicotinamide.
-!- This multiunctional enzyme catalyzes both the synthesis and hydrolysis of cyclic ADP-ribose, a calcium messenger that can mobilize intracellular Ca(2+) stores and activate Ca(2+) influx to regulate a wide range of physiological processes. -!- In addition, the enzyme also catalyzes EC 2.4.99.20. -!- Cf. EC 3.2.2.5.

UniProtKB Entries (1)

P29241
NADA_APLCA
Aplysia californica
ADP-ribosyl cyclase/cyclic ADP-ribose hydrolase

PDB Structure

PDB 1R0S
External Links
Method X-RAY DIFFRACTION
Organism Escherichia
Primary Citation
ADP-ribosyl cyclase; crystal structures reveal a covalent intermediate.
Love, M.L., Szebenyi, D.M., Kriksunov, I.A., Thiel, D.J., Munshi, C., Graeff, R., Lee, H.C., Hao, Q.
Structure