CATH Classification

Domain Context

CATH Clusters

Superfamily 3.30.230.10
Functional Family DNA topoisomerase 2

Enzyme Information

5.6.2.3
DNA topoisomerase (ATP-hydrolyzing).
based on mapping to UniProt P06786
ATP-dependent breakage, passage and rejoining of double-stranded DNA.
-!- The enzyme can introduce negative superhelical turns into double- stranded circular DNA. -!- One unit has nicking-closing activity, and another catalyzes super- twisting and hydrolysis of ATP (cf. EC 5.6.2.2). -!- Formerly EC 5.99.1.3.

UniProtKB Entries (1)

P06786
TOP2_YEAST
Saccharomyces cerevisiae S288C
DNA topoisomerase 2

PDB Structure

PDB 1QZR
External Links
Method X-RAY DIFFRACTION
Organism Escherichia
Primary Citation
Structure of the topoisomerase II ATPase region and its mechanism of inhibition by the chemotherapeutic agent ICRF-187
Classen, S., Olland, S., Berger, J.M.
Proc.Natl.Acad.Sci.USA